Rendimiento Clínico de las Restauraciones Adhesivas con Resina Compuesta en Casos de Pacientes con Desgaste Severo e Incremento de Dimensión Vertical: Revisión de Literatura Sistematizada / Clínical Performance of Adhesive Restorations with Composite Resin in Cases of Patients with Severe Wear and Increased Vertical Dimension: Systematized Literature Review

El desgaste dental severo se describe como la pérdida sustancial de la estructura dental, con exposición de la dentina y pérdida significativa de igual o más de 1/3 de la corona clínica. El uso de materiales compuestos de resina permite al clínico ser más conservador, debido a su aplicación mínimamente invasiva. Además de ello, son relativamente económicas, proporcionan buena estética general, así como un buen rendimiento y facilidad en la reparación. El objetivo de esta revisión de literatura sistematizada es recopilar información disponible en la literatura referente a cuál es el rendimiento clínico de las restauraciones adhesivas con resina compuesta en casos de pacientes con desgaste severo e incremento de la dimensión vertical como objetivo rehabilitador. Se analizaron artículos entre los años 2000 y 2022, seleccionando cuatro bases de datos (Pubmed, Scopus, Scielo y Web of Science). Para identificar los descriptores se utilizó los Medical subject headings (Mesh): Tooth Wear, Composite Restorations, Resin y Oral Rehabilitation. No se aplicó restricciones de idioma, país de origen, autor o lugar de publicación donde se realizó el estudio. Como resultado de la búsqueda se obtuvieron 71 artículos, de los cuales se seleccionaron 5 que cumplieron con los criterios de elegibilidad para ser considerados en la revisión de literatura sistematizada. Se encontró un promedio de tasa de éxito ente el 89,4 % - 100 % en un promedio total de 5.2 años de seguimiento. Se puede concluir, hasta donde se tiene conocimiento en la literatura científica disponible, que el tratamiento de restauraciones adhesivas con resinas compuestas en pacientes con desgaste severo es recomendable, enfocado en un periodo a corto-mediano plazo (3-5 años), siendo una opción de tratamiento económica y mínimamente invasiva.

Severe tooth wear is described as the substantial loss of tooth structure, with dentin exposure and significant loss of equal to or more than 1/3 of the clinical crown. The use of resin composite materials allows the clinician to be more conservative, due to its minimally invasive application. In addition to this, they are relatively inexpensive, provide good general aesthetics, as well as good performance and ease of repair. The objective of this systematic literature review is to collect information available in the literature regarding the clinical performance of adhesive restorations with composite resin in cases of patients with severe wear and increase in the vertical dimension as a rehabilitation objective. Articles between the years 2000 and 2022 were analyzed, selecting four databases (Pubmed, Scopus, Scielo and Web of Science). To identify the descriptors, the Medical subject headings (Mesh) were used: Tooth Wear, Composite Restorations, Resin and Oral Rehabilitation. No language, country of origin, author or place of publication restrictions where the study was conducted were applied. As a result of the search, 71 articles were obtained, of which 5 were selected that met the eligibility criteria to be considered in the systematic literature review. An average success rate between 89.4 % - 100 % was found in a total average of 5.2 years of follow-up. It can be concluded, to the best of our knowledge in the available scientific literature, that the treatment of adhesive restorations with composite resins in patients with severe wear is recommendable, focused on a short-medium term period (3-5 years), being a Inexpensive and minimally invasive treatment option.

Uma nova classe de doenças: doenças autoinflamatórias / A new class of diseases: autoinflammatory diseases

As doenças autoinflamatórias sistêmicas são um grupo de doenças raras recentemente descritas, mas que vêm ganhando espaço no cenário clínico. Caracterizam-se por alterações da imunidade inata, portanto sem a presença de linfócito T autorreator ou autoanticorpo, e que respondem ao bloqueio de uma única citocina. Esta revisão tem como objetivo analisar a base imunofisiológica destas doenças e descrever brevemente cada uma delas com suas características clínicas mais importantes.

Systemic autoinflammatory diseases are a group of rare diseases only recently described but rapidly growing in importance in the clinical setting. They are characterized by innate immunity impairment, i.e., absence of autoreactive T lymphocytes or autoantibodies, and respond to individual cytokine blockade. The objective of this review was to analyze the immunophysiological basis of these diseases and to briefly describe each of them along with their most relevant clinical characteristics.

Perioperative management of drugs commonly used in patients with rheumatic diseases: a review

Rheumatic diseases are very prevalent, affecting about 7 million people in North America; they affect the musculoskeletal system, often with systemic involvement and potential for serious consequences and limitation on quality of life. Clinical treatment is usually long-term and includes drugs that are considered either simple or complex and are occasionally unknown to many health professionals who do not know how to manage these patients in emergency units and surgical wards. Thus, it is important for clinicians, surgeons and anesthesiologists who are involved with rheumatic patients undergoing surgery to know the basic principles of therapy and perioperative management. This study aims to do a review of the perioperative management of the most commonly used drugs in rheumatologic patients. Manuscripts used in this review were identified by surveying MEDLINE, LILACS, EMBASE, and COCHRANE databases and included studies containing i) the perioperative management of commonly used drugs in patients with rheumatic diseases: and ii) rheumatic diseases. They are didactically discussed according to the mechanism of action and pharmacokinetics; and perioperative management. In total, 259 articles related to the topic were identified. Every medical professional should be aware of the types of drugs that are appropriate for continuous use and should know the various effects of these drugs before indicating surgery or assisting a rheumatic patient postoperatively. This information could prevent possible complications that could affect a wide range of patients.

Human islet xenotransplantation in rodents: A literature review of experimental model trends

Among the innovations for the treatment of type 1 diabetes, islet transplantation is a less invasive method of treatment, although it is still in development. One of the greatest barriers to this technique is the low number of pancreas donors and the low number of pancreases that are available for transplantation. Rodent models have been chosen in most studies of islet rejection and type 1 diabetes prevention to evaluate the quality and function of isolated human islets and to identify alternative solutions to the problem of islet scarcity. The purpose of this study is to conduct a review of islet xenotransplantation experiments from humans to rodents, to organize and analyze the parameters of these experiments, to describe trends in experimental modeling and to assess the viability of this procedure. In this study, we reviewed recently published research regarding islet xenotransplantation from humans to rodents, and we summarized the findings and organized the relevant data. The included studies were recent reports that involved xenotransplantation using human islets in a rodent model. We excluded the studies that related to isotransplantation, autotransplantation and allotransplantation. A total of 34 studies that related to xenotransplantation were selected for review based on their relevance and current data. Advances in the use of different graft sites may overcome autoimmunity and rejection after transplantation, which may solve the problem of the scarcity of islet donors in patients with type 1 diabetes.

A temperatura e umidade na degradação de fipronil em dois solos de Mato Grosso do Sul / Temperature and moisture on fipronil degradation in two soils of Mato Grosso do Sul State, Brazil

Este trabalho teve como objetivo avaliar a influência da temperatura e umidade na degradação de fipronil, em condições de laboratório, em dois solos de Mato Grosso do Sul. Os solos (0-30 e 50-70cm) foram incubados nas temperaturas de 30 e 40°C e umidades de 50 e 80% da capacidade de campo. Amostras para análise dos resíduos de fipronil foram retiradas aos 0, 3, 10, 17, 24, 34 e 44 dias, sendo os dados das quantidades remanescentes em função do tempo ajustados aos modelos de cinética de primeira ordem e bifásico. O aumento da umidade e temperatura favoreceu a degradação do fipronil em ambos os solos. O modelo de cinética de primeira ordem mostrou-se superior ao bifásico para descrever a degradação do fipronil com valores de meia-vida entre 19 e 74 dias.

This research had the aim to evaluate the influence of temperature and moisture on fipronil degradation under laboratory conditions of two soils at Mato Grosso do Sul State. Soil samples (0-30 and 50-70cm) were incubated at temperatures of 30 and 40°C and soil moistures of 50 and 80% field capacity. Soil samples for fipronil residue analysis were collected at 0, 3, 10, 17, 24, 34, and 44 days after application and remaining amount data as a function of time were fitted to first-order kinetic and biphasic models. Temperature and soil moisture increase did improve fipronil degradation for both soils. First-order kinetics model did show a better performance than biphasic model to describe fipronil degradation with half-life values between 19 and 74 days.

Leaf dislodgeable residues of deltamethrin applied in different types of formulations in staked cucumbers

Pesticide residues, especially in fruit and vegetsble production, raise worries about the consumers' health and the workers who need to return to the treated crops with these pesticides. The objective of this work was to study the occurence and behavior of dislodgeable residues of deltamethrin pyrethroid inseticide, applied in different types of formulations on leaves of a staked cucumber crop as a starting point for occupation exposure studies. The treatments were: (a)control; (b)three applications of 30 mL Decis 25 EC.100 L-1 water; (d) three applications of 3.75 mL Decis 200 CS.100 L-1 water. All decis treatments consisted of 0.75 g a.i deltamethrin 100L-1 water. Samples were taken (-1); zero; 1; 3; 5; 7 and 14 days after the last application. The analytical method consisted of the extraction of deltamethrin residues with Sur-ten solution, clean-up of the extracts by gel permeation chromatography (GPC), with elution made with a mixture of ethyl acetate/cyclohexane. The quantitative determination was done by gas chromatograph, using electron capture detector. The dislodgeable residues of deltamethrin were righerin CS as compared to the both EC's (4-20 times), with hal-life values of 2.8; 3.8 and 32.2 days, respectively for the formulation ma pose higher danger to workers, it is emphazide the need of the proper use of individual protection equipament when applying thse chemicals or returning to treated areas to perform other crop tasks...

Verificação de requisitos de segurança de tratores agrícolas em alguns municípios do estado de São Paulo / Checking security requirements for tractors in some regions in the state of São Paulo

Um levantamento de informações foi realizado com o objetivo de avaliar as condições de segurança de tratores agrícolas novos e usados em alguns municípios do estado de São Paulo. Foram avaliados 487 tratores em uso em 270 propriedades agrícolas do estado de São Paulo e 31 tratores novos disponíveis em revendas e em exposição em feiras agrícolas, sendo inspecionados alguns requisitos de segurança relativos a posto de operação, acesso, comandos, proteção de partes móveis, disponibilização de avisos contra riscos de acidentes e requisitos necessários para tráfego em rodovias, previstos em documentos normativos nacionais e/ou internacionais. Verificou-se que os tratores em uso no campo não favorecem a segurança e o conforto do operador, enquanto que os tratores novos mostram tendência de atendimento aos requisitos de segurança e conforto, principalmente aqueles relacionados ao posto de operação e à proteção de partes ativas.

A survey was held in some regions in the state of São Paulo aiming at evaluating safety conditions in used and brand new tractors. 487 tractors in use in 270 farms in the state of São Paulo were analyzed together with 31 brand new ones displayed in shops and fairs. The following were checked: the driver's seat, its accessibility, position of controls, protection against the active parts of the engine, warning signs disposal and consonance to the national and international safety regulations for highways driving. The final result showed that while the used tractors offer no comfort or security to the driver, the brand new ones seem to fulfill the requirements, mainly those related to the driver's seat and the protection of the engine active parts.

Metabolism of carbosulfan to carbofuran and to 3-hydroxy-carbofuran in orange leaves

The biochemical degradation pathway of pesticides under field conditions can yield metabolites that require a more complete toxicological evaluation once they might be so or even more toxic than the parent compounds. The objective of this study was to evaluate the metabolism of the inseticide/acaricide carbosulfan to carbofuran and to 3-hydroxy-carbofuran, based on their residues in orange leaves. Two field experiments were carried out, both with the following treatments: a - control; b - one application of 10 g of carbosulfan . 100 L-1 of water; c - one application with twice the amount applied in treatment b; d - four applications with the same amount applied in treatment b. Samples were taken at (-1), zero, 1, 3, 7, 14, 21 and 28 days after the last or unique application. The quantitative determinations were done by by gas chromatography, using a nitrogen-phosphorus detector. The carbosulfan metabolism to carbofuran was fast and both had low persistence in the leaves (3 days). The same trend was observed for the carbofuran metabolism to 3-hydroxy-carbofuran, which was produced in very low amount and rapidly dissipated

Pirimiphos-methyl residues in corn and popcorn grains and in some of their processed products

Insecticides are used for stored cereal protection against insect attack and the occurrence of their residues needs to be evaluated not only in grain but also in the processed products. This study evaluates the residue degradation/persistence of the organophosphorous insecticide pirimiphos-methyl in corn and popcorn grains and in some of their processed products such as bran, hominy and corn flour from corn and popped popcorn. Grains were treated with pirimiphos-methyl at the rate of 12 mg.kg-1 (a.i.). Samples were taken and analyzed at zero, 15, 30, 60, 120 and 240 days after treatment. The analytical method consisted of residue extraction with acetone, clean-up partition with acetonitrile/hexane and silica gel column chromatography eluted with a mixture of hexane + acetone. Quantitative measurements were made by gas chromatography, using flame photometric detector (GLC/FPD). The limits of quantitation (LOQs) were: corn grain, hominy and popped popcorn 0.05 mg.kg-1; bran, corn flour and popcorn grain 0.1 mg.kg-1. Pirimiphos-methyl residues were not persistent in either types of grains or in their processed products. At the end of sampling period (240 days), 5 to 8-fold less residues were found in corn bran and popcorn. Hominy and corn flour showed low levels of contamination. Higher residue concentrations in corn bran than in grains are related to the higher oil content in that processed product

Perfil dos acidentes rurais em agências do INSS de São Paulo no ano 2000 / Agricultural accidents diagnosis in public health (system) agencies in São Paulo - year 2000

Levantamento realizado com o objetivo de caracterizar os acidentes rurais registrados em agências da previdência social. Foram amostradas dez agências no estado de São Paulo tomando-se como base o ano de 2000. Os acidentes foram avaliados em termos da distribuição percentual das seguintes características: perfil do acidentado (sexo, idade, estado civil), tarefa em execução na ocasião do acidente, natureza da causa do acidente, tipo de agente da lesão, partes do corpo atingidas, tipos de lesões e conseqüência do acidente (dias de afastamento, ocorrência de internação). Um total de 949 registros de acidentes foram identificados. Dos inúmeros relatos de acidentes apresentados observou-se que: a grande maioria deles está relacionada à colheita manual de produtos agrícolas (41,7 %) sendo as ferramentas manuais a natureza predominante das causas (34,3 %) e os ferimentos/contusões o tipo de lesão mais comum (68,9 %). O principal agente da lesão foram as batidas contra objetos ou partes mecânicas (43,8 %) sendo os membros superiores os mais atingidos (43,2 %).

It was made a sampling with the aim to study the agricultural accidents in Public Health agencies. Ten agencies were consulted in São Paulo state on the year 2000. The accidents were evaluated by the percentual distribution of follows data: characteristics of victim in an accident (sex, age, marital status); activity executed when occurred the accident; nature of cause; agent of injury; affected body members; kinds of lesions and result of accident (resting) days, overnights in hospital). It was identified 949 records of accidents and had been observed that the major was related to manual picking (41,7 %) which manual tools were the principal accidents causes (34,3 %) and the most injuries were trauma/notch (68,9 %). The main agent of injury was hit against mechanical parts or objects (43,8 %) and the higher limbs of the body were the most affected (43,2 %).